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Although it was determined that residues 47 and 101 were critical to the maintenance of catalytic activity, the protein: - protein interactions between GST π and JNK appear to be distal from, and independent of, the catalytic site of GST π

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showed stable retinopathy, in terms of outer retinal structure and visual function, for up to 9 years after hydroxychloroquine cessation in eyes with early and moderate retinopathy but progressive retinopathy for up to 20 years after drug cessation in cases of severe retinopathy (Pham and Marmor, 2019)