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Flavonoids, a prominent subclass of polyphenols, exhibit additional protective mechanisms

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Mechanistic studies have shown that oxidative stress further upregulates 5-LOX expression by activating the Nrf2 signaling pathway, forming a vicious cycle of “oxidative stress-lipid peroxidation”, which leads to impaired humoral immune function and the expansion of myeloid-derived suppressor cells (MDSCs), thereby promoting tumor immune escape (160)