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Therefore, even if PHD-2 is inactivated by competitive inhibition of α-ketoglutarate by pyruvate, FIH-1 remains active and prevents HIF-1α transcriptional activity (Rani et al., 2022)

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In humans, surgical removal of intra-abdominal adipose tissue by omentectomy during bariatric surgery has been shown to either decrease insulin and glucose levels (122) or to have no effect on components of the metabolic syndrome and insulin resistance (123, 124)