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The second biosynthetic feature of the PPP is the production of NADPH(H + ), making up to 65–70% of its total content in the cell, which is necessary for the biosynthesis of fatty acids, cholesterol, bile acids, and steroid hormones
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[58] pyruvate, which is the only source of endogenous lactate in the brain, is at a crossroads of a number of metabolic pathways i.e
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