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14 It recommends rapid initiation of alternate-day intramuscular hydroxocobalamin therapy, and maintenance of this treatment until all symptoms have resolved or there is no further neurological improvement, with long term B 12 therapy depending on the presence of deficiency on presentation, together with total abstinence from the use of nitrous oxide

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DSIP is a nine-amino-acid neuropeptide first isolated from the cerebral venous blood of rabbits in 1974 by Swiss neurophysiologist Marcel Monnier and his colleagues at the University of Basel

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