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The gene showed low activity in stationary macrophages (M0), increases in pro-inflammatory differentiated cells (M1 macrophages), and decreases in cells differentiating into anti-inflammatory macrophages (M2 macrophages) (69)
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The data showed that free curcumin levels peaked in the plasma for 10 and 12 g doses at times of 3.29 ± 0.43 h and 6.77 ± 0.83 h, with peak concentrations of 2.3 ± 0.26 μg/mL and 1.73 ± 0.19 μg/mL respectively ( Most of the curcumin detected in the plasma was in its conjugate forms, where the ratio of glucuronide: to sulfate was 1.92:1 ( Phase 1 metabolism As seen in Figure 3, during the phase 1 metabolism process in the epithelium cells, curcumin undergoes reduction catalyzed by NADPH-reductase, yielding dihydro curcumin, tetrahydro curcumin, hexahydro curcumin, and octa-hydro curcumin (phase 1 metabolites)
