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A computer-aided search of PUBMED, Google Scholar, EmBase, Scopus, and ERIC databases from inception through June 2021 was conducted to identify pertinent publications using the search terms ‘autism’, ‘autistic’, ‘Asperger’, ‘ASD’, ‘pervasive’, and ‘pervasive developmental disorder’ in all combinations with the terms “MB12”, “Methylcobalamin”, “Cobalamin”, “B12”, “Cyanocobalamin”, “Hydroxycobalamin”, “Adenosylcobalamin”, and “Vitamin B12.” References cited in identified publications were also searched to locate additional studies