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Prior culture studies using dapsone alone and in combination with other intracellular antibiotics (tetracyclines, rifampin, azithromycin) had shown that dapsone as a single drug and in combination with doxycycline +/− rifampin as well as doxycycline + rifampin + azithromycin had the most significant effect in reducing the mass, viability, and protective mucopolysaccharide (MPS) layers of B