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The 2026 Sports Medicine and JAAOS Global Research and Reviews papers (PMID 41966639, PMID 41490200) place multiple compounds — including this one — into the wider research context of unapproved compounds under active investigation, with attention to both the mechanism findings and the regulatory framing that researchers consulting these reviews should weigh equally
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Piperine was also included in the ‘not prohibited’ group, based on a description by AIS found in the characterization of curcumin from group B, which states, ‘curcumin is an unstable compound and its bioavailability is very poor in its unmodified form
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