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Sucrose preference test (SPT) and water intake Test Sucrose preference test (SPT) is a sensitive screening test as a measure of anhedonia in rodents, a decline in SPT shows a significant face validity for chronic stress and antidepressant treatment (Razmjou, et al., 2015

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Likewise, vascular contributions to cognitive decline account for approximately 25% of all dementia cases [500], yet are supported by robust diagnostic frameworks, including neuroimaging (e.g., MRI), and standardized treatment protocols