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Pyruvate then enters the mitochondrial matrix and proceeds to the TCA cycle, where it is ultimately oxidized

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These cells recognize pathogen-associated molecular patterns (PAMPs) present in fungal surface like galactomannan and β-1,3-glucan among others, through pathogen-recognition receptors (PRR) such as Toll-like receptors (specially TLR-1,−3,−4, and-6), the C-type lectin receptor-Dectin-1 ( Aspergillus recognition leads to the generation of proinflammatory cytokines like IL-1α, IL-1β, TNF-α, IL-8, and MIP-1α by activation of the NFkB and inflammasome pathways ( AM are also capable of eliminating directly conidia and initiate an inflammatory response to fungal infection