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Studies suggest that various molecular pathways are involved in IC/BPS, including the JUN N-terminal kinase (JNK) pathway, transient receptor potential (TRP) channels, activated mast cells, mucosal signalling, circadian rhythm regulation, inflammation and neural dysregulation

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One of these compounds was found to be a new asymmetrical cyclobutane dimer of 5,6-dehydrokawain (Nishidono et al., 2020)