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This follows its role as a cytoprotection mediator transmitting the mucosal integrity maintenance to other organs therapy [1,2,3,4,5,6,7,8,9,10,11,15,27,28,29,30,33,109,124,125] in consideration of the regular dietary taking (dietary nitrate as an important source of NO in mammals [252]), and nitrate-nitrite-NO pathway (and swallowed nitrite) resulting with high NO concentration in the stomach [253]
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For example, a small number of subjects reported the following mild side effects in the course of a four-week glutathione study at the dose of 1g/day [13]: Flatulence Loose stools Flushing Weight gain In a more specialized study involving cystic fibrosis patients and much higher glutathione doses, some of the patients reported tightness in the torso, diarrhea, and fever-like symptoms [14]