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NAC replenishes depleted GSH levels in Human immunodeficiency virus (HIV) patients (4, 5), prevents contrast-induced nephropathy (6), and has demonstrated therapeutic potential in psychiatric disorders, neurodegenerative diseases, infertility, cancer, ophthalmic, and gastrointestinal conditions (7–12)
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While initially a consequence of oxidative damage, this downregulation appears to reflect a protective response aimed at minimizing further ROS generation
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