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Four hours later, mice were administered drugs morphine (10 mg/kg/d, sc), U50, 488H (30 mg/kg/d, sc), Kratom alkaloid extract (100 mg/kg/d, po), mitragynine (30 mg/kg/d, po), or 7-OH (1 mg/kg/d

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In these cases, B12 injections provide a direct source of the vitamin, circumventing the digestive system and aiding in absorption