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Crucially, B2A exhibits strong specificity toward BMPs, with no response to other growth factors such as fibroblast growth factor-2 (FGF-2), TGF-β1, and vascular endothelial growth factor

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Bringing it into a topical lotion is the newer step and that research is still building, so it works here as a second angle on tone alongside Niacinamide rather than a substitute for it