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The pattern is consistent: strong mechanistic plausibility from preclinical data and adjacent human safety, no direct human efficacy or long-term safety data on IGF-1 LR3 itself

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Characteristic microscopic presentation at 2 h (1, 2, 8, 9) or 24 h (3 – 7, 10 – 13) after oral strong alcohol administration (1 ml/rat), at the tongue, and swallowed