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Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis

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The key events are the disruption of the mitochondrial membrane integrity, triggering cytochrome c release, regulation of the mitochondrial permeability through the Bcl-2 family proteins (anti-apoptotic Bcl-2 vs pro-apoptotic Bax), and the formation of the apoptosome by cytochrome c, activating caspase-9 and downstream effector caspases (e.g., caspase-3) (Kannan and Jain, 2000