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Intimate areas, such as the genital-perineal area, perianal area, mons pubis, inner thighs, and groins, can sometimes experience darkening or hyperpigmentation

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This suggests that prophylactic or early intervention with anti-inflammatory agents that block upstream pathways like NF-κB or p38 MAPK following a known insult (noise trauma) could potentially decouple the inflammatory response from the triggering event, preventing maladaptive neural plasticity and the development of tinnitus