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[197] constructed three different DNA nanostructures and found that DNA nanostructures could significantly enhance the intracellularization of platinum drugs, thereby increasing their anticancer activity not only against conventional A549 cells but also more importantly against cisplatin-resistant (CisR) cancer cells (A549 CisR), thus effectively inhibiting tumor growth, suggesting that DNA nanostructures are effective carriers for platinum precursor drug delivery to counter chemotherapy resistance