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In a recent study (Fortier and Matte, 2006), we have shown that the improved selenium status of sows via supplementation with organic selenium (0.3 ppm Se as Sel-Plex® selenium yeast) has drastic consequences for embryos

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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers