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Also, read: 7 Days Diet Chart for Diabetic Patients Other Possible Causes: Other possible causes of numbness include the following: Autoimmune conditions like multiple sclerosis can cause numbness throughout the body, including the legs and feet Infectious conditions-shingles Medications, which are known to cause neuropathy as a secondary effect (chemotherapy) Numbness: Symptoms and Signs If you are experiencing numbness in your legs and feet, you might also experience other symptoms besides the numb feeling: Tingling: You might feel like your limbs are experiencing "pins-and-needles" or a prickly sensation