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While much evidence indicate that B cell-derived IL-10 production is strongly down-regulated in MS patients (Duddy et al., 2007, Bar-Or et al., 2010), only few studies have characterized so far B reg populations in MS by using different Ab cocktails leading to contrasting results (Knippenberg et al., 2011, Michel et al., 2014, Li et al., 2015, Habib et al., 2015)