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Nevertheless, results from recent interventional studies favor a causal role of homocysteine in the onset of cardiovascular disease

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While multi-component dietary interventions specifically designed to enhance glutathione status have not yet been studied, it is interesting note that feeding mice a western-style diet impaired hepatic glutathione synthesis and lowered plasma levels [156], and that, in humans, higher adherence to a traditional-Mediterranean style diet is associated with higher plasma glutathione [157]