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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

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However, presence of reactive oxygen, nitrogen or chlorine species (R–O/N/C–S) can either directly or indirectly cause a variety of different thiol modifications [67–69], which affect enzymatic activities, protein-protein interactions, susceptibility towards other post-translational modifications, protein turnover and/or sub-cellular localizations [16,70,71]