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Interestingly, inhibitory BDNF factors due to hypermethylation were recently found to be reversible by consuming hypermethylation-rich diets with methyl donors (i.e., folate, choline, B vitamins) and packing and providing polyphenol food compounds (through histone acetylation) provides a more accessible chromatin state to initiate gene expression [231]

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Stimuli-responsive nanomedicines for overcoming cancer multidrug resistance