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Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity | Cell Death & Disease

Additionally, the inflammatory microenvironment is an important factor influencing the regeneration of cartilage tissue, which can inhibit the differentiation of MSCs such as chondrocytes, leading to chondrocyte death and hypertrophy, extracellular matrix decomposition, and even promoting the progression of osteoarthritis [436]

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