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Efficacy and Safety of Low Doses of Trazodone in Patients Affected by Painful Diabetic Neuropathy and Treated with Gabapentin: A Randomized Controlled Pilot Study | CNS Drugs | Springer Nature Link

Both examples reinforce the view that other mechanisms beyond solely triplication of Hsa21 are involved to explain the wide phenotypic variation occurring in DS individuals

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Next-day appetite control Evening injection means you wake up with the medication already circulating at meaningful levels