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The Framingham study demonstrated a prevalence of 12% among elderly people living in the community.10 Other studies focusing on elderly people, particularly those who are in institutions or who are sick, have suggested a higher prevalence: 30%–40%.11 , 12 However, these figures are questionable since they depend directly on normality thresholds selected by the authors

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Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum