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Results showed that replacement of the eastern amide bond of the parent malonamide by the trifluoroethylamine moiety led to 23-fold and 11-fold decrease in activity for c-Met (IC 50 = 0.70 μ M) and VEGFR2 (IC 50 = 0.21 μ M), respectively, compared to compound 212 (IC 50 = 0.03 μ M and IC 50 = 0.02 μ M for c-Met and VEGFR2, respectively)
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