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Amplification of Oxygen-Independent Free Radicals Based on a Glutathione Depletion and Biosynthesis Inhibition Strategy for Photothermal and Thermodynamic Therapy of Hypoxic Tumors | ACS Applied Materials & Interfaces

NRF2 mediates an increase in the content and activity of p-GP transporters, thereby limiting the increase in membrane permeability (Shchulkin et al., 2021)

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The reliance on glycolysis leads to a high lactate/pyruvate ratio (LPR) due to the reduction of pyruvate into the waste product lactate, which is associated with hypoxia