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Research in aged animals has demonstrated that NAD+ supplementation can restore DNA repair capacity to more youthful levels, with studies showing 30-50% improvements in repair efficiency following NAD+ precursor administration

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Among the differentially expressed genes, transcripts related to thyroid function were up-regulated (Fig S6A) whereas Nrf2 target genes and Nrf2 regulating genes were shown down-regulated (Fig S6A and D) (Raghunath et al, 2018)