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Based on this, we proposed the idea of a systemic intervention by simultaneous regulation of the main pathophysiological processes of AGA including excessive androgen attack, inflammation and loss of growth activity of hair follicle stem cells [60], and we believe that the simultaneous inhibition of DHT and inflammation, activation of hair follicle stem cells, and stimulation of angiogenesis to improve blood supply on hair follicle growth [56] together may be more effective to promote hair regeneration in AGA