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[DOI] [PubMed] [Google Scholar] 43.Japjec M., Horvat Pavlov K., Petrovic A., Staresinic M., Sebecic B., Buljan M., Vranes H., Giljanovic A., Drmic D., Japjec M., et al
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Folic acid is synthetic, does not exist in nature, and must be converted through DHFR—an enzyme that is extremely slow and variable in humans—before your body can use it.¹ It accumulates in blood as unmetabolized folic acid (UMFA), blocks folate receptors, and competes with active forms