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The Y receptor/NPY hormone family forms a multi-ligand/multi-receptor system in which NPY and PYY display high affinity for the hY 1 R, hY 2 R, and hY 5 R, whereas PP has the highest affinity for the hY 4 R (Pedragosa-Badia et al., 2013)

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Thus, over the years, research has been conducted into the possible link between an even moderate rise in homocysteine levels and cardiovascular risk and mortality, with conflicting results [6,7]