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[PubMed] [Google Scholar] Quimby JM, Gustafson DL, Samber BJ et al: Studies on the pharmacokinetics and pharmacodynamics of mirtazapine in healthy young cats, J Vet Pharmacol Ther (in press)

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These pathological processes led to the abnormal accumulation of neurotoxic metabolites, i.e., KYN and 3-HK, within neurons, which then induced neuronal ferroptosis and associated functional impairment, ultimately manifesting as anxiety-like and depression-like behaviors