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It has been proven that NNMT has a dual mechanism to sustain a DNA hypomethylation state through a high SAH/SAM flux and downregulation of DNMT1 and DNMT3A in a methionine-dependent manner [73]
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Finally, a large proportion of the other studies reviewed herein, including the ones focused on exercise, did not include or report on mitochondrial readouts following NAD + modulation
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