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The Key Factors in the Methylation Cycle We will now consider three important causes of interruption to the methylation cycle: Vitamin B12 deficiency Folate deficiency MTHFR mutation Vitamin B12 deficiency If vitamin B12 is deficient, the methyl group cannot be transferred from methylfolate to the methionine cycle

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Diverticular disease was rarely described in the literature prior to the 1900’s