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When cell membranes are exposed to various stimuli, vast amounts of AA are released from PLs by phospholipase A2 (PLA2) and phospholipase C (PLC) [54,55,56], which is then metabolized into biologically active inflammatory mediators like eicosanoids prostaglandin (PG), interleukin (IL), tumor necrosis factor (TNF), and leukotriene (LT)
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In GCN2-deficient mice fed a high-fat diet, a downregulation of MT-1 and MT-2 was found together with obesity and hepatic steatosis
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