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Under low-iron conditions, IRPs bind to IREs in the untranslated regions (UTRs) of target mRNAs, stabilizing TfR1 and DMT1 transcripts while suppressing translation of ferritin and FPN1

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The protein-loaded nanogel effectively induced a specific IgG in macaques for binding Streptococcus pneumoniae and triggered a complement C3 deposition, resulting in a high bactericidal effect