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Symptoms of this stage of spinal stenosis, if it causes any symptoms, may include: Mild back pain that improves when you lean forward Mild tingling or numbness with long periods of standing or walking Moderate : The area is compromised between ⅓ and ⅔ of its normal size Moderate back pain that flares up when you stand or walk for long periods Numbness, tingling, and/or weakness that radiates to the extremities Severe : The area is compromised to a degree of over ⅔ of its normal size Significant back pain that disrupts your daily routine Significant neurological symptoms, including numbness, tingling, and weakness Discomfort while sitting and standing for any length of time Difficulty balancing, especially while walking Early intervention is key to slowing spinal stenosis progression

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The high-resolution structures revealed that cagrilintide adopts an amylin-like binding mode, characterized by a 'bypass' motif