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[39] In the liver, when ischemia-reperfusion occurs, macrophages alter hepatocyte metabolism (downregulation of FTH and GPX4 and upregulation of ACSL4) and induce ferroptosis by forming lactoferrin-rich extracellular traps and releasing ROS

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352,353 Differentiated ECs polarize and form a vascular lumen, through intracellular vesicle fusion or slit formation, 354 eventually forming major vessels such as aorta or middle cerebral artery after BM deposition