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doi: 10.3389/fcell.2026.1813085 Received 18 February 2026 Revised 27 March 2026 Accepted 06 April 2026 Published 29 April 2026 Volume 14 - 2026 Edited by Maja Jazvinšćak Jembrek, Rudjer Boskovic Institute, Croatia Reviewed by Yi Wu, Chinese Academy of Sciences (CAS), China Brindha Devi P., Vels Institute of Science Technology and Advanced Studies, India Updates Copyright © 2026 Ye, Hong, Liu, Wang, Zhang, Zheng, Yu and Wang

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In clinical trials such as SURPASS-2, tirzepatide demonstrated greater efficacy in type 2 diabetes compared to semaglutide 1 mg, with patients achieving substantial reductions in hemoglobin A1c levels and body weight