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AHK-Cu begins with alanine: Alanine–Histidine–Lysine GHK-Cu begins with glycine: Glycine–Histidine–Lysine Both peptides bind copper, but a small structural difference can influence how a peptide interacts with cells, proteins, and biological pathways

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This happens because the cell membrane becomes depolarized, which then activates various receptors and ion channels, such as N‐methyl‐D‐aspartate (NMDA) receptors, amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolpropionic acid (AMPA) receptors, and voltage‐dependent Na + and Ca 2+ ion channels