mitochondrial glutathione regulation and functions Dual-action mitochondria-targeted prodrugs that both deplete deliver a toxic payload to the matrix Select a Pack:Pack of 1 InsGluReg Current ADC Linker Chemistry

mitochondrial glutathione regulation and functions Dual-action mitochondria-targeted prodrugs that both deplete deliver a toxic payload to the matrix Select a Pack:Pack of 1 InsGluReg Current ADC Linker Chemistry

Current ADC Linker Chemistry - PMC

Reithmeier RAF, Casey JR, Kalli AC, Sansom MSP, Alguel Y, Iwata S

InsGluReg

Select a Pack:Pack of 1

Glossary ALD Alcohol-associated liver disease ALT Alanine aminotransferase AMY Amylase AST Aspartate aminotransferase ATP Adenosine Tri-Phosphate CBS Cystathionine β-synthase cDNA Complementary Deoxyribonucleic acid CSE Cystathionine γ-lyase CTAB Cetyltrimethylammonium bromide Cyp2e1 Cytochrome P450 2E1 Gapdh Glyceraldehyde 3-phosphate dehydrogenase GCL Glutamate-cysteine ligase Gclc Glutamate–cysteine ligase catalytic subunit GPO-POD Glycerol Phosphate Oxidase-Peroxidase Gpx1 Glutathione peroxidase 1 GSH Glutathione H 2 S Hydrogen Sulphide IL-6 Interleukin-6 iNOS Inducible nitric oxide synthase Keap1 Kelch-like ECH-associated protein 1 LPO Lipid peroxidation LPS Lipopolysaccharide MAT Methionine Adenosyl transferase MDA Malondialdehyde MPO Myeloperoxidase NaHS Sodium hydrosulphide NF-κB Nuclear factor kappa B NNDP N, N-dimethyl-p-phenylenediamine sulphate NO Nitric Oxide Nos2 Nitric Oxide Synthase 2 PUFAs Polyunsaturated fatty acids qRT-PCR Quantitative real-time PCR ROS Reactive oxygen species SAH S-adenosyl Homocysteine SAMe S-adenosyl-L-methionine TBA Thiobarbiturate TCA Trichloroacetic acid TGL Triglycerides TNF-α Tumour necrosis factor alpha References 1 Aguilar Diaz De LeonJ.BorgesC