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Animal Model:Naturally aged male C57BL/6 mice (20-24 months old) [1] Dosage:5 mg/kg Administration:Intraperitoneal injection, every other day for three administrations Result:Increased serum testosterone levels

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Activation of peripheral immune cells and systemic inflammation may contribute to neuroinflammation, leading to the activation of microglia and astrocytes with the subsequent release of inflammatory and signaling molecules