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Similar results were observed in the recently evaluated systemic NAM toolbox ( It was clear from our experience with two laboratories, that there is a need to develop and evaluate standardized protocols for dosing methodologies (e.g., Sharma et al

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We demonstrated that the TSS pathway is ineffective in supraphysiological cystine concentrations but is critical under physiological cystine supplementation or excess hemin exposure in SCD erythroblasts