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(2016) described BPC-157 in the context of the brain-gut axis (gut-brain axis) with the NO pathway — regulation of flow in existing vessels, complementary to angiogenesis
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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing — meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
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