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Additionally, pyridoxine therapy alone does not reduce fasting homocysteine and the reduction in postmethionine-load homocysteine levels was smaller for pyridoxine than for the combined therapy using folic acid and pyridoxine (van der Griend et al, 2000)

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The reasons include limited availability of hair follicle donor sites, limited accessibility to specialized equipment, and lengthy treatment duration, which may not be convenient for individuals