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In addition, resveratrol may help treat thyroid cancer since it can induce apoptosis of thyroid cancer cells by increasing the abundance and phosphorylation of p53 tumour suppressor protein (p53) (198, 199)

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In the TME of PCa, prostate stromal cells, especially CAFs, secrete insulin-like growth factors (IGFs), thereby promoting extracellular matrix remodeling (Goel et al., 2006)